Gyrus Group

  A New Alzheimer’s Blood Test: A Diagnostic Breakthrough For decades, the path to a definitive Alzheimer’s disease (AD) diagnosis has been challenging, relying on a combination of cognitive testing, expensive PET scans, or invasive lumbar punctures . A reliable and accessible blood test has long been a primary goal for the field, promising to significantly improve the diagnostic process for both patients and clinicians. A landmark new study from researchers at the Mayo Clinic, published in Alzheimer’s & Dementia, shows that this goal is moving firmly into clinical reality. Their work validates a powerful new blood test using plasma-based biomarkers — marking a significant step forward for both clinical and legal communities. The Breakthrough: A Blood Test with Near-CSF Accuracy Critically, the study evaluated the performance of plasma biomarkers in a real-world setting — a cohort of over 500 patients from an outpatient memory clinic. This population reflects the true...

  Post-traumatic amnesia is a transient state following a traumatic brain injury, where brain function is temporarily altered, disrupting cognitive and behavioural functioning (Parker et al., 2022). The accurate diagnosis of post-traumatic amnesia is critical for understanding the appropriate clinical management and prognosis of the patient following a traumatic brain injury. However, in many cases these impairments are not accurately diagnosed, negatively impacting clinical care as well as medicolegal claims. Post-traumatic amnesia was first described in 1930s by British neurologists Ritchie Russell and Charles Symonds (Russel, 1932; Symonds, 1937). Post-traumatic amnesia refers to the time between the onset of a traumatic brain injury and the time that patients can encode and retrieve new memories. It was noted that patients typically exhibit a range of cognitive, behavioural and perceptual deficits, as well as considerable variation in their clinical presentations. Russell ...

  The Expert Witness Report in Brief Gyrus Group experts receive instructions from insurance or legal firms to provide their expert opinion on how an incident may (or may not) have resulted in a brain injury or illness, and what the consequences of the injury or illness may be for the individual following the incident (if any). In forming their opinion, experts will review relevant documents (such as medical records and employment documents), may perform a clinical examination of the claimant, and will reflect on their own extensive experience in medical practice and on their understanding of the medical literature. Gyrus Group expert reports comply with Part 35 directions, meaning experts understand and confirm that their duty is to the court, and not to their instructor. Gyrus Group maintain a 50:50 balance between instructions received from claimants and defendants. The Expert Witness Gyrus Group’s expert witnesses are practicing medical consultants, specialising in the ...

  Following damage to the central nervous system (CNS), immune cells in the brain, known as microglia, are activated. Microglia are critical for protecting neural function and they have an important role in clearing debris and modulating the inflammatory response. However, following CNS injury , microglia can become dysregulated and play a key role in neurodegeneration. Chahin et al., (2025) recently published in Communications Biology, present an animal model of single and repetitive concussions, which was able to reliably induce cognitive and learning impairments in the absence of deficits in motor function, a key confound in the assessment of cognition. The model did not induce macroscopic brain injury and did not induce hemorrhage, edema, contusion, bruising, skull fracture or cell death. As a result, the model was able to mimic human concussions, where cognitive impairments are typically seen in the absence of abnormalities on neuroimaging scans. Following repetitive con...